Jonathan Lee – Mechanisms of memory persistence


ABOUT

I spent all of my training years at the University of Cambridge, undertaking first a degree in Natural Sciences, specialising in Neuroscience. As part of this, I conducted a research project with Antony Dickinson, who provided me with an invaluable grounding in learning theory. I remained in Cambridge at the Department of Experimental Psychology to pursue a PhD, under the supervision of Barry Everitt and Kerrie Thomas, mainly focussed on the mechanisms of hippocampal contextual fear memory consolidation and reconsolidation. I remained in Barry Everitt's lab as a post-doctoral researcher, applying our understanding of memory reconsolidation first to cocaine self-administration settings, and then to natural reward-seeking settings. I was appointed first to a Departmental Lectureship at the Department of Experimental Psychology in the University of Cambridge, and subsequently to a Lectureship at the School of Psychology in the University of Birmingham. In 2013 I was promoted to Senior Lecturer.

RESEARCH

Our research is principally focussed on memory reconsolidation in rodent associative memory settings. These include auditory fear conditioning, contextual fear conditioning and various appetitive pavlovian conditioning paradigms. We also study initial memory consolidation, as well as extinction of memories. All of these processes come under the umbrella of our Memory Persistence Laboratory.

KEY PUBLICATIONS

Reduction in responding for sucrose and cocaine reinforcement by disruption of memory reconsolidation
Exton-McGuinness, M. & Lee, J. L. C. (2015) eNeuro. 2: 1-17

Inhibition and enhancement of contextual fear memory destabilization
Lee, J. L. C. & Flavell, C. R. (2014) Frontiers in Behavioral Neuroscience. 8: 144

Ventral tegmental dopamine dysregulation prevents appetitive memory destabilization
Reichelt, A. C., Exton-McGuinness, M. T. & Lee, J. L. C. (2013) The Journal of Neuroscience. 33: 14205-10

Reconsolidation: maintaining memory relevance
Lee, J. L. C. (2009) Trends in Neurosciences. 32: 413-420

Memory reconsolidation mediates the strengthening of memories by additional learning
Lee, J. L. C. (2008) Nature Neuroscience. 11:1264-6

Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior
Lee, J. L. C., Di Ciano, P., Thomas, K. L. & Everitt, B. J. (2005) Neuron. 47: 795-801

Independent cellular processes for hippocampal memory consolidation and reconsolidation
Lee, J. L. C., Everitt, B. J. & Thomas, K. L. (2004) Science. 304: 839-43

Full text and complete publication list at 

 

LAB MEMBERS

Find out more about current lab members here.


CONTACT

j.l.c.lee {at} bham.ac.uk